Job Description
We are seeking an innovative and collaborative senior scientist to join our immunotoxicology team at the West Point, PA site. As part of the Investigative Toxicology department within Non-Clinical Drug Safety (NDS), the immunotoxicology group is responsible for developing novel models to inform on human risk assessment, understand mechanisms of toxicity, and support our diverse pipeline.
The successful candidate will drive immunotoxicology research projects through a combination of lab-based efforts and collaboration with other team members. In addition, the candidate is expected to represent the NDS functional area as a program toxicologist on cross-functional drug discovery and development teams.
Key responsibilities include: - Independent design, implementation, and interpretation of in vitro and in vivo investigative tox efforts to support immunotoxicity risk assessment and mechanistic investigations of new drug candidates.
- Conduct immunophenotyping or immune functional assessments on toxicology studies and prepare high quality immunotoxicity assay/study reports.
- Communicate project goals, gaps/risks, and results effectively to Investigative Tox managers and cross-functional stakeholders.
- Timely and accurate documentation of experimental procedures and resulting data in electronic notebooks
- Provide scientific leadership and immunotoxicology subject matter expertise at multidisciplinary team meetings.
- Participate in external immunotoxicology consortia and symposia. Stay updated on the latest scientific research, regulatory guidance, and industry trends to guide informed decisions, drive innovation, and champion new technologies/methods in immunotoxicology safety assessment.
- Serve on cross-functional project teams representing NDS as a program toxicologist on discovery and development teams. Efforts include guiding early target liability assessment and risk assessment strategy for discovery teams, designing nonclinical toxicology studies to support compound development in accordance with internal and regulatory guidance, communicating key topics to team and NDS stakeholders, and authoring regulatory documents.
Qualifications and Experience - PhD in life science, such as Immunology, Toxicology, Biology, Biochemistry, or a related discipline.
- Minimum of 3 years of postdoctoral or industry experience in immunotoxicology or immunology.
- Hands-on experience with flow cytometry, immunoassays (ELISA/ELISPOT), and in-vitro/ in-vivo assays to assess immune function/activity
- Strong communication skills, with the ability to interact effectively with colleagues across multiple teams.
Preferred Experience and Skills - Experience performing and analyzing immunotoxicity assays to support immunotoxicity risk assessment (immunophenotyping, cytokine release assays, functional assays)
- Demonstrated success developing innovative in-vitro or in-vivo models for preclinical investigative toxicology
- Experience leading toxicology evaluation for drug discovery and development teams
- Knowledge of regulatory guidance for biologics and immunotoxicology assessments (ICH S6, ICH S8, ICH S9)
Current Employees apply HERE
Current Contingent Workers apply HERE
US and Puerto Rico Residents Only: Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.
As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:
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U.S. Hybrid Work Model Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote".
The salary range for this role is
$104,200.00 - $163,900.00
This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.
The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.
We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at .
You can apply for this role through (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.
San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance
Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance
Search Firm Representatives Please Read Carefully Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.
Employee Status: Regular
Relocation: Domestic/International
VISA Sponsorship: Yes
Travel Requirements: No Travel Required
Flexible Work Arrangements: Hybrid
Shift: Not Indicated
Valid Driving License: No
Hazardous Material(s): N/A
Required Skills: Assay Development, Assay Development, Bioassay Development, Biomarker Identification, Business, Cell-Based Assays, Cell Culture Techniques, Change Catalyst, Clinical Immunology, Communication, Detail-Oriented, Environmental Toxicology, Enzyme Linked Immunosorbent Assay (ELISA), Experimentation, Exploratory Research, Flow Cytometry, Forensic Toxicology, High-Throughput Screening, Immunoassays, Immunochemistry, Immunology, Innovation, Molecular Biology Techniques, Protein Purifications, Risk Assessments {+ 4 more}
Preferred Skills: Job Posting End Date: 07/4/2025
*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date. Requisition ID: R354526
Job Tags
Holiday work, Full time, For contractors, Local area, Relocation, Visa sponsorship, Flexible hours, Shift work, 3 days per week,